Cayman Chemical JWH 081 5methoxynaphthyl5mg
A PAI-1 inhibitor (IC50 655 nM) selective for PAI-1 over tPA and plasminogen as well as a panel of 40 neurotransmitter endocrine and enzymatic targets at 10 UM enhances cleavage of monomeric and oligomeric AB42 in a cell-free assay at 5 UM reduces plasma AB40 and brain AB40 and AB42 levels in the Tg2576 transgenic mouse model of Alzheimer’s disease at 20 mg/kg reverses cognitive deficits in the same model at 30 and 100 mg/kg